Article

Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology

2021-06-09

Abstract excerpt

<h4>Background: </h4> The vault RNAs (vtRNAs) are a class of 84-141-nt eukaryotic non-coding RNAs transcribed by RNA polymerase III, associated to the ribonucleoprotein complex known as vault particle. Of the four human vtRNA genes, vtRNA1-1, vtRNA1-2 and vtRNA1-3, clustered at locus 1, are integral components of the vault particle, while vtRNA2-1 is a more divergent homologue located in a second locus. Gene expre...

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Literature Corpus work: 39b3dd26-3bf2-5ecf-b9d0-608ed25c0550
DOI: 10.12688/f1000research.28510.2

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