Article

Comprehensive genome and transcriptome analysis reveals genetic basis for gene fusions in cancer

2017-06-12

Abstract excerpt

Gene fusions are an important class of cancer-driving events with therapeutic and diagnostic values, yet their underlying genetic mechanisms have not been systematically characterized. Here by combining RNA and whole genome DNA sequencing data from 1188 donors across 27 cancer types we obtained a list of 3297 high-confidence tumour-specific gene fusions, 82% of which had structural variant (SV) support and 2372 of...

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Literature Corpus work: f33332f5-1e7c-583e-a2a8-11bda54ec8a4
DOI: 10.1101/148684

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