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The Interplay between Mutagenesis and Extrachromosomal DNA Shapes Urothelial Cancer Evolution

2023-05-07

Abstract excerpt

Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity. In this study, we investigate the evolution of the genomic signatures caused by endogenous and external mutagenic stimuli and their interplay with complex structural variants. We superimposed mutational signatures and phylogenetic analyses of matched serial tumors from patients with urothelial cancer to define...

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Literature Corpus work
59c5a324-3583-5ef2-b305-16ea32d3686a
DOI
10.1101/2023.05.07.538753
Open publication

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The Interplay between Mutagenesis and Extrachromosomal DNA Shapes Urothelial Cancer EvolutionDOI 10.1101/2023.05.07.538753
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