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Article

Clonal evolution and mutational trajectories of metastatic colorectal cancer shaped by anticancer therapies.

Nature communications - 13 Jun 2026

Lee Won Hee, Kim Bun, Nam Chang Hyun, Yeo Hyun Yang, Lee Dong Woon, Park Sung Chan, Oh Jae Hwan, Han Sung-Sik, Lim Myong Cheol, Kim Hail, Ju Young Seok, Chang Hee Jin, Cha Yongjun

Abstract excerpt

The evolutionary dynamics of cancer genomes at single-cell resolution under therapeutic pressure remain elusive. Hence, we perform whole-genome sequencing of 58 single-cell-derived tumoroids and 18 matched bulk tumors from six patients with metastatic colorectal cancer. High-resolution phylogenies reveal the clonal evolution of cancer with quantitative and qualitative profiling of therapy-associated mutations at...

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Antineoplastic Agents
Clonal Evolution
Colorectal Neoplasms
Long Interspersed Nucleotide Elements
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Single-Cell Analysis

Whole Genome Sequencing

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Identifiers

PMID: 42288523
DOI: 10.1038/s41467-026-74384-3
PMCID: PMC13408353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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