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Article

Clonal evolution of chemotherapy-resistant urothelial carcinoma.

Nature genetics - 1 Dec 2016

Faltas Bishoy M, Prandi Davide, Tagawa Scott T, Molina Ana M, Nanus David M, Sternberg Cora, Rosenberg Jonathan, Mosquera Juan Miguel, Robinson Brian, Elemento Olivier, Sboner Andrea, Beltran Himisha, Demichelis Francesca, Rubin Mark A

Abstract excerpt

Chemotherapy-resistant urothelial carcinoma has no uniformly curative therapy. Understanding how selective pressure from chemotherapy directs the evolution of urothelial carcinoma and shapes its clonal architecture is a central biological question with clinical implications. To address this question, we performed whole-exome sequencing and clonality analysis of 72 urothelial carcinoma samples, including 16...

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Identifiers

PMID: 27749842
DOI: 10.1038/ng.3692
PMCID: PMC5549141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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