The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution.

doi:10.1038/s41586-024-07955-3

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Article

The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution.

Nature - 1 Nov 2024

Nguyen Duy D, Hooper William F, Liu Weisi, Chu Timothy R, Geiger Heather, Shelton Jennifer M, Shah Minita, Goldstein Zoe R, Winterkorn Lara, Helland Adrienne, Sigouros Michael, Manohar Jyothi, Moyer Jenna, Al Assaad Majd, Semaan Alissa, Cohen Sandra, Madorsky Rowdo Florencia, Wilkes David, Osman Mohamed, Singh Rahul R, Sboner Andrea, Valentine Henkel L, Abbosh Phillip, Tagawa Scott T, Nanus David M, Nauseef Jones T, Sternberg Cora N, Molina Ana M, Scherr Douglas, Inghirami Giorgio, Mosquera Juan Miguel, Elemento Olivier, Robine Nicolas, Faltas Bishoy M

Abstract excerpt

Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity1. In this study, we investigated the evolution of genomic signatures caused by endogenous and external mutagenic processes and their interplay with complex structural variants (SVs). We superimposed mutational signatures and phylogenetic analyses of matched serial tumours from patients with urothelial cancer to...

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PMID: 39385020
DOI: 10.1038/s41586-024-07955-3
PMCID: PMC11541202

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