Article

The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancer

2022-09-05

Abstract excerpt

Mutagenic processes leave distinct signatures in cancer genomes. The mutational signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers. However, data linking individual APOBEC3 proteins to cancer mutagenesis in vivo are limited. Here, we show that transgenic expression of human APOBEC3G promotes mutagenesis, genomic instability, and kataegis, leading to shorter survival in a murine bl...

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Literature Corpus work: 28c673d6-d00c-5ee5-8d47-b47db0ca6cf7
DOI: 10.1101/2022.09.05.503899

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