Article

Spreading α-synuclein rewires organelle communication and impairs neuron–astrocyte mitochondrial quality control

2026-06-23

Abstract excerpt

Progressive intercellular spreading of α-synuclein (αS) is implicated in pathology initiation and propagation of synucleinopathies. However, how recipient neurons respond to incoming αS and whether these responses contribute to disease-associated early metabolic events, remains unknown. Here, using extracellular monomeric αS to model the earliest cellular response to spreading, we found that internalized αS accumu...

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Literature Corpus work: 59826ed7-4d27-5022-b468-7d8fe26e1886
DOI: 10.64898/2026.06.19.733342

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