Article

Spreading of α-synuclein rewires organelle communication and disrupts neuron-astrocyte mitochondrial quality control

2026-07-29

Abstract excerpt

<title>Abstract</title> <p>Progressive intercellular spreading of α-synuclein (αS) is implicated in pathology initiation and propagation of synucleinopathies. However, how recipient neurons respond to incoming αS and whether these responses contribute to disease-associated early metabolic events, remains unknown. Here, using extracellular monomeric αS to model the earliest cellular response to spreading, we found...

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Literature Corpus work: 56e1b985-7fef-56b4-b32b-6ba948fd6130
DOI: 10.21203/rs.3.rs-10396187/v1

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