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Article

Potential Modes of Intercellular α-Synuclein Transmission

22 Feb 2017

Abstract excerpt

Intracellular aggregates of the α-synuclein protein result in cell loss and dysfunction in Parkinson's disease and atypical Parkinsonism, such as multiple system atrophy and dementia with Lewy bodies. Each of these neurodegenerative conditions, known collectively as α-synucleinopathies, may be characterized by a different suite of molecular triggers that initiate pathogenesis. The mechanisms whereby α-synuclein...

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PMID: 28241427
DOI: 10.3390/ijms18020469

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