Article

CRISPRi with barcoded expression reporters dissects regulatory networks in human cells

2024-09-06

Abstract excerpt

Genome-wide CRISPR screens have emerged as powerful tools for uncovering the genetic underpinnings of diverse biological processes. Incisive screens often depend on directly measuring molecular phenotypes, such as regulated gene expression changes, provoked by CRISPR-mediated genetic perturbations. Here, we provide quantitative measurements of transcriptional responses in human cells across genome-scale perturbati...

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Literature Corpus work: 5965d670-ca70-576f-b9ad-c7405efc81aa
DOI: 10.1101/2024.09.06.611573

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