Article

Global analysis of specificity determinants in eukaryotic protein kinases

2017-09-27

Abstract excerpt

Protein kinases lie at the heart of cell signalling processes, constitute one of the largest human domain families and are often mutated in disease. Kinase target recognition at the active site is in part determined by a few amino acids around the phosphoacceptor residue. These preferences vary across kinases and despite the increased knowledge of target substrates little is known about how most preferences are en...

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Literature Corpus work: 9eb7c4ae-5162-5bac-bc89-62fab92dbaff
DOI: 10.1101/195115

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