Article

Hierarchical organization endows the kinase domain with regulatory plasticity

2017-10-02

Abstract excerpt

<h4>ABSTRACT</h4> The functional diversity of kinases enables specificity in cellular signal transduction. Yet general rules for how the kinase domain allows the more than 500 members of the human kinome to receive specific regulatory inputs and convey information to appropriate substrates – all while using the common signaling currency of phosphorylation – remain enigmatic. Here, using co-evolution analysis and...

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Literature Corpus work: 08ef58fd-e2b8-5776-8c21-5f5eba45e640
DOI: 10.1101/197491

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