Article

Substrate-derived peptides for selective covalent inhibition of protein tyrosine kinases

2026-05-14

Abstract excerpt

Protein tyrosine kinases are important regulators of cell signaling, and aberrant kinase activity contributes to many human diseases, including cancers. All protein tyrosine kinases share a highly-conserved ATP binding pocket but diverge in their substrate binding sites in order to mediate distinct signaling events. Many potent and efficacious ATP-competitive tyrosine kinase inhibitors have been developed, however...

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Literature Corpus work: 4e15da8b-b795-5406-90ef-9514f28b2b87
DOI: 10.64898/2026.05.11.724146

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