Article

Cushing’s Syndrome mutant PKA <sup>L205R</sup> exhibits altered substrate specificity

2016-12-05

Abstract excerpt

The PKA L205R hotspot mutation has been implicated in Cushing’s Syndrome through hyperactive gain-of-function PKA signaling, however its influence on substrate specificity has not been investigated. Here, we employ the Proteomic Peptide Library (ProPeL) approach to create high-resolution models for PKA WT and PKA L205R substrate specificity. We reveal that the L205R mutation reduces canonical hydrophobic prefer...

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Identifiers and source

Literature Corpus work: bed87836-adbe-5c54-8abe-4d8f027c4d5e
DOI: 10.1101/091231

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