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Article

The mechanism of Parkin activation by PINK1 phosphorylation

2019-01-01

Abstract excerpt

Mutations in the E3 Ub ligase Parkin (PARK2) and the protein kinase PINK1 (PARK6) are genetically linked to Young-Onset Parkinson's Disease. The two enzymes orchestrate clearance of damaged, cytotoxic mitochondria through a specialized form of autophagy termed mitophagy. By phosphorylating ubiquitin (Ub) on the surface of damaged mitochondria, PINK1 generates a phospho-Ub receptor for autoinhibited cytosolic Parki...

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Identifiers and source

Literature Corpus work
593f30bb-66f5-508a-a4ea-ecd35a726462
DOI
10.17863/cam.41674
Open publication

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The mechanism of Parkin activation by PINK1 phosphorylationDOI 10.17863/cam.41674
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