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Article

Mechanism of phospho-Ubls' specificity and conformational changes that regulate Parkin activity.

Structure (London, England : 1993) - 7 Nov 2024

Lenka Dipti Ranjan, Chaurasiya Shradha, Ratnakar Loknath, Kumar Atul

Abstract excerpt

PINK1 and Parkin mutations lead to the early onset of Parkinson's disease. PINK1-mediated phosphorylation of ubiquitin (Ub), ubiquitin-like protein (NEDD8), and ubiquitin-like (Ubl) domain of Parkin activate autoinhibited Parkin E3 ligase. The mechanism of various phospho-Ubls' specificity and conformational changes leading to Parkin activation remain elusive. Herein, we show that compared to Ub, NEDD8 is a more...

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Identifiers

PMID: 39368463
DOI: 10.1016/j.str.2024.09.012

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