Article
Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex.
Molecular cell - 6 Jan 2022
Rasool Shafqat, Veyron Simon, Soya Naoto, Eldeeb Mohamed A, Lukacs Gergely L, Fon Edward A, Trempe Jean-François
Abstract excerpt
Mutations in PINK1 cause autosomal-recessive Parkinson's disease. Mitochondrial damage results in PINK1 import arrest on the translocase of the outer mitochondrial membrane (TOM) complex, resulting in the activation of its ubiquitin kinase activity by autophosphorylation and initiation of Parkin-dependent mitochondrial clearance. Herein, we report crystal structures of the entire cytosolic domain of insect PINK1....
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