Article

Mechanism of PINK1-mediated ubiquitin phosphorylation

2018-01-01

Abstract excerpt

Ubiquitin phosphorylation by PINK1 (PTEN-induced Putative Kinase 1) is crucial for mitochondrial quality control and loss or mutation of PINK1 can lead to autosomal recessive juvenile parkinsonism (AR-JP). PINK1 is an unusual kinase, as it is characterised by three unique insertions in its kinase N lobe and a C-terminal region after the kinase domain. Despite great effort, a structure of PINK1 could not be determi...

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Literature Corpus work: 54010d50-5f33-56e6-97c7-4118a9d48c25
DOI: 10.17863/cam.24555

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