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Article

Activation of the E3 ubiquitin ligase Parkin.

Biochemical Society transactions - 1 Apr 2015

Caulfield Thomas R, Fiesel Fabienne C, Springer Wolfdieter

Abstract excerpt

The PINK1 (phosphatase and tensin homologue-induced putative kinase 1)/Parkin-dependent mitochondrial quality control pathway mediates the clearance of damaged organelles, but appears to be disrupted in Parkinson's disease (PD) [Springer and Kahle (2011) Autophagy 7, 266-278]. Upon mitochondrial stress, PINK1 activates the E3 ubiquitin (Ub) ligase Parkin through phosphorylation of the Ub-like (UBL) domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25849928
DOI: 10.1042/BST20140321
PMCID: PMC4859148

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Ubiquitin is phosphorylated by PINK1 to activate parkin.Semantic proximity Read ↗

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PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.Semantic proximity Read ↗

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