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Article

Mechanism of phospho-ubiquitin-induced PARKIN activation.

Nature - 20 Aug 2015

Wauer Tobias, Simicek Michal, Schubert Alexander, Komander David

Abstract excerpt

The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal-recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy. PINK1 is stabilized on the outside of depolarized mitochondria and phosphorylates polyubiquitin as well as the PARKIN ubiquitin-like (Ubl) domain. These phosphorylation events lead...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26161729
DOI: 10.1038/nature14879
PMCID: PMC4984986

Genes

PINK1
RING1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of parkin by a molecular glue.Semantic proximity Read ↗

Ubiquitin is phosphorylated by PINK1 to activate parkin.Semantic proximity Read ↗

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