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Article

A mechanistic review of Parkin activation.

Biochimica et biophysica acta. General subjects - 1 Jun 2021

Gundogdu Mehmet, Tadayon Roya, Salzano Giulia, Shaw Gary S, Walden Helen

Abstract excerpt

Parkin and phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) constitute a feed-forward signalling pathway that mediates autophagic removal of damaged mitochondria (mitophagy). With over 130 mutations identified to date in over 1000 patients with early onset parkinsonism, Parkin is considered a hot spot of signalling pathways involved in PD aetiology. Parkin is an E3 ligase and how its activity is...

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Identifiers

PMID: 33753174
DOI: 10.1016/j.bbagen.2021.129894

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