Article

An <i>in-silico</i> approach to study the molecular interaction of the PINK1 kinase domain with Parkin Ubl domain

2023-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s Disease (PD) is the second most common neurodegenerative disorder which creates devastating effects on the neurons of the mid brain. PARK2 and PARK6 genes encode the E3 ubiquitin ligase Parkin and serine/threonine protein kinase PINK1 (PTEN-induced kinase 1), respectively. Mutations in these proteins are responsible for majority of the early onset of PD. PINK1 protein along with Park...

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Literature Corpus work: e4918bcf-e006-552a-bc74-26d2b06ee871
DOI: 10.1101/2023.05.02.539044

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