Article
Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.
Nature communications - 9 Mar 2017
Tang Matthew Y, Vranas Marta, Krahn Andrea I, Pundlik Shayal, Trempe Jean-François, Fon Edward A
Abstract excerpt
Parkin and PINK1 function in a common pathway to clear damaged mitochondria. Parkin exists in an auto-inhibited conformation stabilized by multiple interdomain interactions. The binding of PINK1-generated phospho-ubiquitin and the phosphorylation of the ubiquitin-like (Ubl) domain of Parkin at Ser65 release its auto-inhibition, but how and when these events take place in cells remain to be defined. Here we show...
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