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Article

Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2017

Aguirre Jacob D, Dunkerley Karen M, Mercier Pascal, Shaw Gary S

Abstract excerpt

Mutations in PARK2 and PARK6 genes are responsible for the majority of hereditary Parkinson's disease cases. These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-induced kinase 1 (PINK1), respectively. Together, parkin and PINK1 regulate the mitophagy pathway, which recycles damaged mitochondria following oxidative stress. Native parkin is inactive and exists in an autoinhibited state...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28007983
DOI: 10.1073/pnas.1613040114
PMCID: PMC5240717

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.PMID 28007983Read ↗

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