Article
Activation of parkin by a molecular glue.
Nature communications - 19 Sept 2024
Sauvé Véronique, Stefan Eric, Croteau Nathalie, Goiran Thomas, Fakih Rayan, Bansal Nupur, Hadzipasic Adelajda, Fang Jing, Murugan Paramasivam, Chen Shimin, Fon Edward A, Hirst Warren D, Silvian Laura F, Trempe Jean-François, Gehring Kalle
Abstract excerpt
Mutations in parkin and PINK1 cause early-onset Parkinson's disease (EOPD). The ubiquitin ligase parkin is recruited to damaged mitochondria and activated by PINK1, a kinase that phosphorylates ubiquitin and the ubiquitin-like domain of parkin. Activated phospho-parkin then ubiquitinates mitochondrial proteins to target the damaged organelle for degradation. Here, we present the mechanism of activation of a new...
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