Article

MtDNA heteroplasmy controls tumor immune reprogramming through mitochondrial translation

2026-02-03

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are among the most frequent genetic alterations in human cancers, yet their molecular mechanisms in shaping tumor progression and metastasis under physiological conditions remain poorly understood. Here, we show that mtDNA heteroplasmy acts as a tumor cell–intrinsic rheostat that orchestrates fate decisions between progression and suppression. Moderate heteroplasmy induces a ‘ri...

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Literature Corpus work: 593ef09f-62ff-5f4a-a8eb-91b658905054
DOI: 10.64898/2026.01.31.693596

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