Article

The Macrophage Niche as a Primary Oncogenic Architect: A Two-Hit Systems Biology Hypothesis

2026-07-07

Abstract excerpt

Traditional oncology treats cell-intrinsic somatic mutations as absolute cancer initiators, viewing the immune microenvironment merely as a late-stage promoter. This paper introduces the Two-Hit Systems Biology Model, inverting this framework by proposing that oncogenesis begins with a primary genetic, epigenetic, or functional malfunction within Tissue-Resident Macrophages (TRMs)—constituting Hit 1 (The Permissiv...

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Literature Corpus work: fb288774-7c5a-5e16-ae12-663b6a8935b1
DOI: 10.20944/preprints202607.0435.v1

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