Article
Mitochondrial genome alterations in cancer: From mutations and epigenetics to targeted therapiesack.
Biochemical and biophysical research communications - 3 Sept 2026
Shetty Sachin, Padmasali Nisarga M, Adiga Divya, Kabekkodu Shama Prasada
Abstract excerpt
Mitochondria play a central role in cellular energetics, metabolism, and apoptosis, and their dysfunction is increasingly recognized as a hallmark of cancer. The mitochondrial genome encodes essential subunits of oxidative phosphorylation (OXPHOS) complexes, tRNAs, and rRNAs, which are critical for mitochondrial functions. However, mitochondrial DNA (mtDNA) lacks protective histones and efficient repair...
Topics
- Humans
- Neoplasms
- Epigenesis, Genetic
- Mutation
- Genome, Mitochondrial
- Animals
- DNA, Mitochondrial
- Molecular Targeted Therapy
- Metabolic Reprogramming
- Mitochondria
- Oxidative Phosphorylation