Immune evasion through mitochondrial transfer in the tumour microenvironment.

doi:10.1038/s41586-024-08439-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Immune evasion through mitochondrial transfer in the tumour microenvironment.

Nature - 1 Feb 2025

Ikeda Hideki, Kawase Katsushige, Nishi Tatsuya, Watanabe Tomofumi, Takenaga Keizo, Inozume Takashi, Ishino Takamasa, Aki Sho, Lin Jason, Kawashima Shusuke, Nagasaki Joji, Ueda Youki, Suzuki Shinichiro, Makinoshima Hideki, Itami Makiko, Nakamura Yuki, Tatsumi Yasutoshi, Suenaga Yusuke, Morinaga Takao, Honobe-Tabuchi Akiko, Ohnuma Takehiro, Kawamura Tatsuyoshi, Umeda Yoshiyasu, Nakamura Yasuhiro, Kiniwa Yukiko, Ichihara Eiki, Hayashi Hidetoshi, Ikeda Jun-Ichiro, Hanazawa Toyoyuki, Toyooka Shinichi, Mano Hiroyuki, Suzuki Takuji, Osawa Tsuyoshi, Kawazu Masahito, Togashi Yosuke

Abstract excerpt

Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack1. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lymphocytes (TILs) impair antitumour immune responses2-4. However, detailed mechanisms of such processes remain unclear. Here we analyse clinical specimens and identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Checkpoint Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Evasion

Share to Lymphocytes, Tumor-Infiltrating

Share to Melanoma

Share to Mitophagy

Share to Reactive Oxygen Species

Share to Tumor Escape

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 39843734
DOI: 10.1038/s41586-024-08439-0
PMCID: PMC11798832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immune evasion through mitochondrial transfer in the tumour microenvironment.PMID 39843734Read ↗

The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistanceSemantic proximity Read ↗

Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasionSemantic proximity Read ↗

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defencesSemantic proximity Read ↗

A novel computational tool for tracking cancer energy hijacking from immune cellsSemantic proximity Read ↗

Targeted Anti-Mitochondrial Therapy: The Future of OncologySemantic proximity Read ↗

MtDNA heteroplasmy controls tumor immune reprogramming through mitochondrial translationSemantic proximity Read ↗

Cancer cells hijack T-cell mitochondriaSemantic proximity Read ↗

Intercellular Mitochondrial Transfer in the Tumor MicroenvironmentSemantic proximity Read ↗

Mitochondrial DNA mutation enhances sensitivity to immunotherapy in melanoma.Semantic proximity Read ↗

Unlocking immune responses via mitophagy genes: A dual-pronged strategy against hematologic tumorsSemantic proximity Read ↗

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockadeSemantic proximity Read ↗

Targeting mitochondria in cancer: current concepts and immunotherapy approachesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.