Article

Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy

2024-04-04

Abstract excerpt

<h4>SUMMARY</h4> How genetic lesions drive cell transformation and whether they can be circumvented without compromising function of non-transformed cells are enduring questions in oncology. Here we show that in mature T cells—in which physiologic clonal proliferation is a cardinal feature— constitutive MYC transcription and Tsc1 loss in mice modeled aggressive human malignancy by reinforcing each other’s oncog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 363a1f0c-8bb2-57f5-a6bc-1fbb15c0037e
DOI: 10.1101/2024.04.03.587917

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell MalignancyDOI 10.1101/2024.04.03.587917Read

Oncogenic mutation-driven metabolism-immunity regulatory axis: Potential prospects for thyroid cancer precision therapy.Semantic proximity Read

The Macrophage Niche as a Primary Oncogenic Architect: A Two-Hit Systems Biology HypothesisSemantic proximity Read

MtDNA heteroplasmy controls tumor immune reprogramming through mitochondrial translationSemantic proximity Read

Survival of the fittest: Cancer challenges T cell metabolismSemantic proximity Read

Acetyl-CoA Carboxylase Obstructs CD8 <sup>+</sup> T-Cell Lipid Utilization and Energy Synthesis in the Tumor MicroenvironmentSemantic proximity Read

Harnessing the Co-vulnerabilities of Amino Acid-Restricted CancersSemantic proximity Read

Understanding the "lethal" drivers of tumor-stroma co-evolutionSemantic proximity Read

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogrammingSemantic proximity Read

Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype.Semantic proximity Read

Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable VulnerabilitySemantic proximity Read

Dysregulation of the TSC-mTOR pathway in human diseaseSemantic proximity Read

TCR-T Modulation and Epigenetic Reprogramming for a Personalised Therapeutic Approach in ImmunotherapySemantic proximity Read