Article

KCC2 Activation Reverses Neurophysiological and Behavioral Deficits in Female Rett Mice

2026-01-14

Abstract excerpt

Rett syndrome is an X-linked neurodevelopmental disorder resulting from mutations in the MeCP2 gene, leading to intellectual disability, impaired motor coordination, decreased sociability, and seizures. Central to the underlying pathophysiology are deficits in synaptic inhibition, which are mediated by hyperpolarizing GABA A R currents. These events develop postnatally and are dependent upon increased neuronal Cl...

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Literature Corpus work: 592fbfbc-dc71-5632-943a-27c4875b3a50
DOI: 10.64898/2026.01.13.699303

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