Article
Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation.
Human molecular genetics - 15 Jan 2014
Lang Min, Wither Robert G, Colic Sinisa, Wu Chiping, Monnier Philippe P, Bardakjian Berj L, Zhang Liang, Eubanks James H
Abstract excerpt
Mutations of the X-linked gene encoding methyl CpG binding protein type 2 (MECP2) are the predominant cause of Rett syndrome, a severe neurodevelopmental condition that affects primarily females. Previous studies have shown that major phenotypic deficits arising from MeCP2-deficiency may be reversible, as the delayed reactivation of the Mecp2 gene in Mecp2-deficient mice improved aspects of their Rett-like...
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