Article
Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype.
Biological psychiatry - 1 May 2016
Patrizi Annarita, Picard Nathalie, Simon Alex Joseph, Gunner Georgia, Centofante Eleonora, Andrews Nick Arthur, Fagiolini Michela
Abstract excerpt
BACKGROUND: Rett syndrome (RTT) is a neurological disorder caused by mutation of the X-linked MECP2 gene, which results in the progressive disruption of excitatory and inhibitory neuronal circuits. To date, there is no effective treatment available for the disorder. Studies conducted in RTT patients and murine models have shown altered expression of N-methyl-D-aspartate receptors (NMDARs). Genetic deletion of the...
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