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Article

Alterations of cortical and hippocampal EEG activity in MeCP2-deficient mice.

Neurobiology of disease - 1 Apr 2010

D'Cruz Jennifer Anne, Wu Chiping, Zahid Tariq, El-Hayek Youssef, Zhang Liang, Eubanks James H

Abstract excerpt

Rett syndrome is a pediatric neurological condition caused by mutations of the gene encoding the transcriptional regulator MECP2. In this study, we examined cortical and hippocampal electroencephalographic (EEG) activity in male and female MeCP2-deficient mice at symptomatic stages during different behavioral states. During acute sleep, MeCP2-deficient mice displayed normal delta-like activity in cortex and...

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Source

Identifiers

PMID: 20045053
DOI: 10.1016/j.nbd.2009.12.018

Genes

MECP2

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