Article
KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2016
Tang Xin, Kim Julie, Zhou Li, Wengert Eric, Zhang Lei, Wu Zheng, Carromeu Cassiano, Muotri Alysson R, Marchetto Maria C N, Gage Fred H, Chen Gong
Abstract excerpt
Rett syndrome is a severe form of autism spectrum disorder, mainly caused by mutations of a single gene methyl CpG binding protein 2 (MeCP2) on the X chromosome. Patients with Rett syndrome exhibit a period of normal development followed by regression of brain function and the emergence of autistic behaviors. However, the mechanism behind the delayed onset of symptoms is largely unknown. Here we demonstrate that...
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