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Article

Electrographic and pharmacological characterization of a progressive epilepsy phenotype in female MeCP2-deficient mice.

Epilepsy research - 1 Feb 2018

Wither Robert G, Colic Sinisa, Bardakjian Berj L, Snead O Carter, Zhang Liang, Eubanks James H

Abstract excerpt

Rett Syndrome is a neurodevelopmental disorder caused primarily by mutations in the gene encoding Methyl-CpG-binding protein 2 (MECP2). Spontaneous epileptiform activity is a common co-morbidity present in Rett syndrome, and hyper-excitable neural networks are present in MeCP2-deficient mouse models of Rett syndrome. In this study we conducted a longitudinal assessment of spontaneous cortical electrographic...

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Source

Identifiers

PMID: 29414525
DOI: 10.1016/j.eplepsyres.2018.01.015

Genes

MECP2

Provenance

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