Article

Lineage-specific and context-dependent dynamics of immune checkpoint receptors define activation-associated programs in human γδ T cells

2026-06-29

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Immune checkpoint receptors (ICRs) are widely used as markers of T-cell exhaustion, yet their interpretation remains context-dependent and is poorly described in γδ T cells. Here, we investigated the dynamics, functional impact, and differentiation-associated distribution of ICRs across human γδ and aβ T-cell subsets. <bold>Methods:</bold> Peripheral blood...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58f4036b-7541-5492-8429-a419f8cf5866
DOI: 10.21203/rs.3.rs-10087888/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lineage-specific and context-dependent dynamics of immune checkpoint receptors define activation-associated programs in human γδ T cellsDOI 10.21203/rs.3.rs-10087888/v1Read

Checkpoint receptors in circulating γδ T cells can discern the outcome of cancer immunotherapySemantic proximity Read

CD8 T Cell Exhaustion During Chronic Viral Infection and CancerSemantic proximity Read

T cell receptor γδ is a critical, real-time determinant of unique tissue surveillance mechanismsSemantic proximity Read

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy responseSemantic proximity Read

Immune Checkpoints are Predominantly Co-Expressed by Clonally Expanded CD4+FoxP3+ Intratumoral T-cells in Primary Human CancersSemantic proximity Read

Effector Vδ1 γδT cells mediate anti-tumor immunity and are reprogrammed by imatinib in human gastrointestinal stromal tumorSemantic proximity Read

Tissue‐Resident Memory CD8+ T Cells: Differentiation, Phenotypic Heterogeneity, Biological Function, Disease, and TherapySemantic proximity Read

A pan-cancer gamma delta T cell repertoireSemantic proximity Read

CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionSemantic proximity Read

Immunogenomic, single-cell and spatial dissection of CD8 + T cell exhaustion reveals critical determinants of cancer immunotherapySemantic proximity Read

A genome-wide innateness gradient defines the functional state of human innate T cellsSemantic proximity Read

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and functionSemantic proximity Read