Article

Immune Checkpoints are Predominantly Co-Expressed by Clonally Expanded CD4+FoxP3+ Intratumoral T-cells in Primary Human Cancers

2023-07-21

Abstract excerpt

<title>Abstract</title> <bold>Background.</bold> Besides anti-PD(L)1, anti-CTLA-4 and anti-LAG-3, novel immune checkpoint proteins (ICP)-targeted antibodies have recently failed to demonstrate significant efficacy in clinical trials. In those trials, patients were enrolled without screening for drug target expression. Although those novel ICP-targeted antibodies were expected to stimulate anti-tumor CD8 + T-ce...

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Literature Corpus work: da88b488-fe6d-5d4a-ae00-a571ab48dd40
DOI: 10.21203/rs.3.rs-3171786/v1

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