Article

Immunogenomic, single-cell and spatial dissection of CD8 <sup>+</sup> T cell exhaustion reveals critical determinants of cancer immunotherapy

2021-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Tumoural-CD8 + T cells exhibit exhausted or dysfunctional states. Contrary to immunotherapy-responsive exhausted-CD8 + T cells, the clinical features of dysfunctional-CD8 + T cells are disputed. Hence, we conducted large-scale multi-omics and multi-dimensional mapping of CD8 + T cell-states across multiple cancer patient-cohorts. This identified tumour-specific continuum of CD8 + T cell-sta...

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Literature Corpus work: 9ae69b1d-4284-5b67-abec-cf9f745daf9d
DOI: 10.1101/2021.11.22.468617

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