Article

Effector Vδ1 γδT cells mediate anti-tumor immunity and are reprogrammed by imatinib in human gastrointestinal stromal tumor

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Gamma-delta (γδ) T cells are emerging effectors of anti-tumor immunity, but their relevance to gastrointestinal stromal tumor, the most common human sarcoma, is not defined. Here, we integrate single-cell transcriptomics, immunophenotypic and T cell receptor profiling, and functional assays of circulating and intratumoral γδ T cells across 68 human GIST specimens. Vδ1 cells predominated...

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Literature Corpus work: e98f4ab6-153a-51ea-8f01-ffab9d3ae1e2
DOI: 10.21203/rs.3.rs-9557741/v1

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