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Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

20 Sept 2022

Abstract excerpt

Background Immune checkpoint blockade (ICB) partially reverses the dysfunctional state of antigen-specific T cell in chronic infections. However, its impact on the diverse subsets of CD4+ T cells in humans is largely unknown. Methods We examined immune checkpoint (IC) expression and function in HIV-specific CD4+ T cells of viremic individuals (≥5000 vRNA cp/ml, n = 17) prior to ART and persons with spontaneous (...

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PMID: 36150362
DOI: 10.1016/j.ebiom.2022.104254

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