Article

A genome-wide innateness gradient defines the functional state of human innate T cells

2018-03-12

Abstract excerpt

Innate T cells (ITCs), including invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells, and γδ T cell populations, use conserved antigen receptors generated by somatic recombination to respond to non-peptide antigens in an innate-like manner. Understanding where these cells fit in the scheme of immunity has been a puzzle since their discovery. Here, immunophenotyping of 101 individua...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f2011b7-d5b1-502f-b527-8902e7c47e2d
DOI: 10.1101/280370

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genome-wide innateness gradient defines the functional state of human innate T cellsDOI 10.1101/280370Read

Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse ModelsSemantic proximity Read

Activation and <i>in vivo</i> evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionalitySemantic proximity Read

Single cell resolution analysis of multi-tissue derived human iNKT cells reveals novel transcriptional paradigmsSemantic proximity Read

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activationSemantic proximity Read

Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cellsSemantic proximity Read

Single-Cell RNA-Seq Analysis Uncovers Distinct Functional Human NKT Cell Sub-Populations in Peripheral BloodSemantic proximity Read

Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models.Semantic proximity Read

Uni-TINT: Unifying T and Innate Lymphoid Cell Taxonomy with a high resolution, pan-disease and pan-tissue single-cell transcriptomic atlasSemantic proximity Read

Human CD8+ T-Cell Populations That Express Natural Killer ReceptorsSemantic proximity Read

Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cellsSemantic proximity Read

Reproducible single cell annotation of programs underlying T-cell subsets, activation states, and functionsSemantic proximity Read

Human MAIT cells show clonal diversity but transcriptional and functional homogeneitySemantic proximity Read