Article

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

2026-05-21

Abstract excerpt

The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming growth factor beta (TGFβ) signaling is among principal regulators of SMC contractility, we studied metabolic regulation of TGFβ signaling in SMCs in vitro and atherosclerotic mouse models and human lesions. We found tha...

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Literature Corpus work: 58eed360-15d0-53c2-9c04-0a09b60c2276
DOI: 10.64898/2026.05.19.726223

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