Article
G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
American journal of physiology. Heart and circulatory physiology - 1 Mar 2021
Dhagia Vidhi, Kitagawa Atsushi, Jacob Christina, Zheng Connie, D'Alessandro Angelo, Edwards John G, Rocic Petra, Gupte Rakhee, Gupte Sachin A
Abstract excerpt
We aimed to determine 1) the mechanism(s) that enables glucose-6-phosphate dehydrogenase (G6PD) to regulate serum response factor (SRF)- and myocardin (MYOCD)-driven smooth muscle cell (SMC)-restricted gene expression, a process that aids in the differentiation of SMCs, and 2) whether G6PD-mediated metabolic reprogramming contributes to the pathogenesis of vascular diseases in metabolic syndrome (MetS)....
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