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Article

SIRT3 Represses Vascular Remodeling via Reducing Mitochondrial Ac-CoA Accumulation in Vascular Smooth Muscle Cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2025

You Mei, Wang Bowen, Li Li, Liu Min, Wang Lijuan, Cao Tingbing, Zhou Qing, Mou Aidi, Wang Hongya, Sun Min, Lu Zongshi, Zhu Zhiming, Yan Zhencheng, Gao Peng

Abstract excerpt

BACKGROUND: Vascular remodeling characterized by vascular smooth muscle cell (VSMC) phenotypic switching is a key pathological process leading to numerous cardiovascular diseases, often accompanied by a decrease in mitochondrial oxidative phosphorylation. However, whether VSMC mitochondrial homeostasis plays a central role in vascular remodeling remains elusive. In this study, we investigated the role of SIRT3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kruppel-Like Factor 4

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Source

Identifiers

PMID: 40242869
DOI: 10.1161/ATVBAHA.125.322428

Genes

SIRT3
KLF4
ACLY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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