Article
Targeting PDK4 attenuates neointimal hyperplasia and regulates VSMC phenotypic switching, apoptosis, and autophagy.
Biochemical pharmacology - 1 May 2026
Sarkar Ankan, Ahmed Sakeel, Singh Monika, Zargar Zahid Bashir, Pawar Sandip V, Sharma Shyam Sunder, Chopra Kanwaljit, Jain Manish
Abstract excerpt
Neointimal hyperplasia, a predominant cause of restenosis and atherosclerosis, is regulated by the phenotypic modulation, migration and proliferation, of vascular smooth muscle cells (VSMCs). Pyruvate dehydrogenase kinase 4 (PDK4) has been identified as a key metabolic regulator linked to cancer cell proliferation. However, the specific mechanistic role of PDK4 in VSMC function and neointimal formation remains...
Topics
- Animals
- Apoptosis
- Muscle, Smooth, Vascular
- Autophagy
- Mice
- Neointima
- Male
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase
- Mice, Inbred C57BL
- Myocytes, Smooth Muscle
- Hyperplasia
- Cells, Cultured
- Phenotype
- Cell Proliferation