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Article

Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia.

The Journal of pathology - 1 Apr 2023

Cao Kaixiang, Zhang Tiejun, Li Zou, Song Mingchuan, Li Anqi, Yan Jingwei, Guo Shuai, Wang Litao, Huang Shuqi, Li Ziling, Hou Wenzhong, Dai Xiaoyan, Wang Yong, Feng Du, He Jun, Fu Xiaodong, Xu Yiming

Abstract excerpt

Switching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to a dedifferentiated (proliferative) phenotype contributes to neointima formation, which has been demonstrated to possess a tumor-like nature. Dysregulated glucose and lipid metabolism is recognized as a hallmark of tumors but has not thoroughly been elucidated in neointima formation. Here, we investigated the cooperative role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36640260
DOI: 10.1002/path.6052

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