Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.

doi:10.1126/sciadv.aef6065

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Article

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.

Science advances - 28 Aug 2026

Zhang Rong-Mo, Zhu Xiaolong, Bae Hosung, Zhang Jiasheng, Li Yanming, Chen Pei-Yu, Shen Ying H, Tellides George, Snyder Nathaniel, Jang Cholsoon, Schwartz Martin A, Arany Zoltan, Simons Michael

Abstract excerpt

The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming growth factor beta (TGFβ) signaling is among principal regulators of SMC contractility, we studied metabolic regulation of TGFβ signaling in SMCs in vitro and atherosclerotic mouse models and human lesions. We found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42647644
DOI: 10.1126/sciadv.aef6065
PMCID: PMC13510649

Genes

PDK4
ACSS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.