Article

Targeted Sequencing of the 9p21.3 Region Reveals Association with Reduced Disease risks in Ashkenazi Jewish Centenarians

2023-05-23

Abstract excerpt

Genome-wide association studies (GWAS) have pinpointed the chromosomal locus 9p21.3 as a genetic hotspot for various age-related disorders. Common genetic variants in this locus are linked to multiple traits, including coronary artery diseases, cancers, and diabetes. Centenarians are known for their reduced risk and delayed onset of these conditions. To investigate whether this evasion of disease risks involves di...

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Literature Corpus work: 58be6d12-8598-5f4b-be14-447f0589e5ce
DOI: 10.1101/2023.05.19.23290237

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